S0590 Video Capsule Endoscopy as First Procedure for Acute Gastrointestinal Bleeding: An Approach to Minimizing Exposure to SARS-CoV-2 and Conserving Resources

INTRODUCTION: Video capsule endoscopy (VCE) has been proposed as an alternative triaging tool for diagnosis of hematemesis and non-hematemesis (GIB) Randomized controlled trials have shown higher detection rates of bleeding with VCE when used as the first procedure compared with standard of care (SOC) This approach been shown to be safe, and well tolerated VCE is particularly suitable for the diagnosis of GIB in suspected/established SARS-CoV-2 (COVID) patients as it requires minimal patient contact (one staff person) to set up, and it avoids aerosolization and sedation We used VCE as the first diagnostic modality in hemodynamically stable patients with GIB Here we report the outcomes of the first 50 patients undergoing VCE in the COVID era as compared to 57 historical controls in the pre-COVID era METHODS: Hemodynamically stable patients with suspected GIB/severe anemia admitted to our hospital between March and May 2020 and who underwent VCE as the first line diagnostic modality composed the experimental group Demographic, clinical, and outcome data was collected and analyzed The control group comprised of patients undergoing evaluation for GIB by SOC at our hospital in January 2020 Continuous variables were compared using Student t-test Categorical variables were compared using Fisher's exact test RESULTS: Patients in both groups had similar baseline characteristics, except COVID cohort was slightly older More patients in the COVID cohort presented with melena and fewer presented with hematochezia as their manifestation of their GIB This difference was only significant for hema-tochezia Bleeding could be localized in 38 (76%) of the COVID cohort patients as compared to 36 (63%) of the historical controls using the first diagnostic modality, P 0 05 significant Only 22 (44%) of the VCE patients underwent additional invasive diagnostic/therapeutic maneuvers and the majority were spared more invasive testing Only 13 (26%) of the VCE patients, as compared to 47 (82%) of the historical controls underwent upper endoscopy for evaluation of GIB There was no significant difference in transfusion requirements, degree of hemoglobin drop, in-hospital mortality, re-admission or rebleeding rates between the two groups CONCLUSION: VCE appears to be a safe alternative to traditional diagnostic evaluation of GIB in the era of COVID It reduced risk of exposure of staff to endoscopic aerosols, conserved personal protective equipment and reduced staff utilization