Melatonin protects against isoproterenol-induced alterations in cardiac mitochondrial energy-metabolizing enzymes, apoptotic proteins, and assists in complete recovery from myocardial injury in rats.
2012
The present study was undertaken to explore the protective effect
of melatonin against isoproterenol bitartrate (ISO)-induced rat myocardial
injury and to test whether melatonin has a role in preventing myocardial
injury and recovery when the ISO-induced stress is withdrawn. Treatment for
rats with ISO altered the activities of some of the key mitochondrial enzymes
related to energy metabolism, the levels of some stress proteins, and the
proteins related to apoptosis. These changes were found to be ameliorated
when the animals were pretreated with melatonin at a dose of 10 mg/kg BW,
i.p. In addition to its ability to reduce ISO-induced mitochondrial
dysfunction, we also studied the role of melatonin in the recovery of the
cardiac tissue after ISO-induced damage. Continuation of melatonin
treatment in rats after the withdrawal of ISO treatment was found to reduce
the activities of cardiac injury biomarkers including serum glutamate
oxaloacetate transaminase (SGOT), lactate dehydrogenase (LDH), and
cardio-specific LDH1 to control levels. The levels of tissue lipid peroxidation
and reduced glutathione were also brought back to that seen in control
animals by continued melatonin treatment. Continuation of melatonin
treatment in post-ISO treatment period was also found to improve cardiac
tissue morphology and heart function. Thus, the findings indicate
melatonin�s ability to provide cardio protection at a low pharmacological
dose and its role in the recovery process. Melatonin, a molecule with very low
or no toxicity may be considered as a therapeutic for the treatment for
ischemic heart disease.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
63
References
51
Citations
NaN
KQI