Synthesis and PDF inhibitory activities of novel benzothiazolylidenehydroxamic acid derivatives

Wataru Takayama,Yoshihisa Shirasaki,Yusuke Sakai,Emi Nakajima,Shuhei Fujita,Kanako Sakamoto-Mizutani,Jun Inoue

Synthesis and PDF inhibitory activities of novel benzothiazolylidenehydroxamic acid derivatives

2003

Wataru Takayama
Yoshihisa Shirasaki
Yusuke Sakai
Emi Nakajima
Shuhei Fujita
Kanako Sakamoto-Mizutani
Jun Inoue

A novel series of benzothiazolylidenehydroxamic acid derivatives has been designed and synthesized as PDF inhibitors. Some of this novel class of PDF inhibitors exhibited micromolar order enzyme inhibitory activity and antibacterial activity.

Keywords:

Enzyme
Peptide deformylase
Organic chemistry
Hydroxamic acid
Biological activity
Inhibitory postsynaptic potential
Biochemistry
Enzyme inhibitor
Chemistry
Antibacterial activity
antibacterial agent
Chemical synthesis

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