Diagnosis of Tuberculous Meningitis Due to Detection of ESAT-6-Specific Gamma Interferon Production in Cerebrospinal Fluid Enzyme-Linked Immunospot Assay

A coma patient was diagnosed with tuberculous meningitis by the detection of ESAT-6-specific gamma interferon-secreting cells in the patient's cerebrospinal fluid by enzyme-linked immunospot assay prior to the identification of the pathogen in a culture of the cerebrospinal fluid.