Enhancement of the myotic response of rabbits with pilocarpine-loaded polybutylcyanoacrylate nanoparticles

Abstract In vivo studies of pilocarpine loaded to polybutylcyanoacrylate nanoparticles were carried out with albino rabbits. A prolonged pilocarpine-induced myosis was achieved with pilocarpine-nanoparticle adsorbates compared to a commercial pilocarpine solution. With nanoparticles containing incorporated drug no significant prolongation of the myotic effect was observed. A two-chamber diffusion cell with a cellophane membrane was found to be unsuitable for in vitro release studies.