Dynamic Fuzziness During Linker Histone Action
2012
Linker histones are multi-domain nucleosome binding proteins that stabilize higher order chromatin structures and engage in specific protein-protein interactions. Here we emphasize the structural and functional properties of the linker histone C-terminal domain (CTD), focusing on its intrinsic disorder, interaction-induced secondary structure formation and dynamic fuzziness. We argue that the fuzziness inherent in the CTD is a primary molecular mechanism underlying linker histone function in the nucleus.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
93
References
8
Citations
NaN
KQI