[Effects of short veno-venous hemofiltration on severe acute pancreatitis].

Objective To estimate the effects of therapy of short veno venous hemofiltration (SVVH, 4hr) on severe acute pancreatitis (SAP). Methods Twenty patients were divided randomly into hemofiltration group (HF, 10 pts) and non hemofiltration group (NHF,10 pts). The local, systemic manifestations were compared between two groups; and the concentration of serum pro inflammatory cytokines (TNFα, IL 1β, IL 6 , IL 8 , sIL 2R) and anti inflammatory cytokines (IL 2, IL 10) were determined at different observation points. Results In the HF and NHF group, the duration for disappearance of abdominal pain and tenderness,and amelioration for abdominal distension was (8 5±6 3)d vs.(90 0±49 0)d and (16 9±5 2)d vs. (63 4±36 0) d. CT scores at the 14th day and APACHEⅡ scores at the 10th day was (5 6±1 3) vs. (7 7± 0 8) and (4 5±1 5) vs. (7 4±2 1). The average hospital stay and cost of therapy were (33 0±20 7)d vs. (56 4±16 0)d and (53200±16000) vs. (89100±25000) RMB( P 0 05). The concentration of 5 serum pro inflammatory cytokines at each observation points after hemofiltration was decreased significantly ( P 0 05) in the HF group. But the concentration of the two serum anti inflammatory cytokines was increased significantly ( P 0 05) as compared with that of the NHF group. Conclusions Through SVVH, the imbalance of pro inflammatory and anti inflammatory cytokines has been corrected at early stage; thus,the severity of the disease is ameliorated significantly and the efficacy of therapy is increased.