Base-promoted Multicomponent Reactions: A Synthesis of 2-Amino-1,3-Selenazole Derivatives

A new practical synthesis of 2-amino-1,3-selenazole with transition-metal-free multicomponent reaction was reported here. A series of 2-amino-1,3-selenazole derivatives were afforded by the nucleophilic addition of amines to an isoselenocyanate formed in situ, followed by a Michael addition reaction and aromatization. The products were isolated from moderate to excellent yields.