Transgenic Overexpression of the Extra-Large Gsα Variant XLαs Enhances Gsα-Mediated Responses in the Mouse Renal Proximal Tubule in Vivo

Zun Liu,Hiroko Segawa,Cumhur Aydin,Monica Reyes,Reinhold G. Erben,Lee S. Weinstein,Min Chen,Vladimir Marshansky,Leopold F. Fröhlich,Murat Bastepe

Transgenic Overexpression of the Extra-Large Gsα Variant XLαs Enhances Gsα-Mediated Responses in the Mouse Renal Proximal Tubule in Vivo

2011

Zun Liu
Hiroko Segawa
Cumhur Aydin
Monica Reyes
Reinhold G. Erben
Lee S. Weinstein
Min Chen
Vladimir Marshansky
Leopold F. Fröhlich
Murat Bastepe

Targeting XLαs expression to the mouse renal proximal tubule augments Gsα-mediated responses and mitigates the PTH-resistance phenotype observed in mice with maternal Gsα ablation.

Keywords:

G protein
In vivo
Endocrinology
Parathyroid hormone
Phenotype
Transgene
Biology
Internal medicine
Cell culture
Gs alpha subunit
Kidney

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