Synthesis of Cationic Cholesterol Derivatives with Succinyl Spacer Group

Syntheses of N,N,N-trimethyl[2-(3β-cholesteryloxy)syccinyloxyethyl]ammonium iodide, N,N-dimethyl-N-2-hydroxyethyl[2-(3β-cholesteryloxy)syccinyloxyethyl]ammonium iodide, and N-[(3β-cholesteryloxy)syccinyl]piperazine were performed. The compounds synthesized in a liposomal form may be used for delivery of genetical material into cells.