Assessment of Thyroid Hormones in Sudanese Patients with Down syndrome

th October, 2015 Background: The close relationship between thyroid disorder and Down syndrome (DS) had been widely reported in the literature. Objectives: The objective of this study, is to estimate the thyroid function test (TSH, T3, and T4) in patients with Down syndrome. Methodology: This is a case control study conducted in Khartoum state during the period from January to May 2015. The blood sample was obtained from 35 patients with DS and 35 apparently healthy as a control, with age ranged between 6 to 17 year with matching age and sex with patients. The samples analyzed for Thyroid hormones by full automated chemistry analyzer TOSOH AIA 360. Result: The (mean± SD) of serum TSH, T3, T4 in DS respectively, were (4.7±2.8, 0.6±0.5, 7.2±2.5), while in the control groups were (1.5±1.6, 0.8±0.2, 10.7±1.3), P. values < 0.05. Conclusion: This study conducted that, T3and T4 in is significantly decreased in Down syndrome compared to control group and also TSH is significantly increased in DS compared to control groups.