P587 : Focal application of 100% trichloroacetic acid for the treatment of seborrheic keratosis on the scalp area: a case series

Seborrheic keratoses are the most common tumor of the epidermis. For clearly benign and cosmetically unwanted lesions, destruction with cryosurgery, electrodesiccation, curettage, or ablative laser systems have been shown to be effective. However, common complications of these destructive therapies include scarring, pigmentary change, incomplete removal, or recurrence. It is more desirable to ensure that the method of removal minimizes the risk of scarring. Trichloroacetic acid (TCA) is a versatile peeling agent and widely used for medium-depth peeling. The higher the concentration or the amount of the TCA applied, the more intense the destructive effect is. Therefore, it may represent a new strategy for skin tumor treatment. We report the case series of eleven patients diagnosed as seborrheic keratosis on the scalp who were treated with focal application of 100% TCA solution between 2011 and 2014. Clinical improvement was evaluated using the 5-point global assessment scale (GAS). Eight of eleven patients (72.7%) had good (50-75% clearance) or excellent (75-100% lesion clearance) results by GAS. No complications, such as scarring alopecia, erythema, or pigmentary changes, were observed. In conclusion, the focal application of 100% TCA for the treatment of seborrheic keratosis on the scalp was clinically effective and safe therapy that can minimize the risk of scarring alopecia.