Clinical study of jugular vein blood oxygen saturation in patients with acute cerebral infarction

Objective To investigate the changes in cerebral oxygen metabolism following acute cerebral infarction and their value for predicting prognosis.Methods Thirty five patients with acute cerebral infarction were enrolled and divided into two groups: severe group (22 cases, GCS≤8) and non-severe group (13 cases, GCS8). Blood samples were obtained through jugular catheter and then jugular vein blood oxygen saturation (SjvO_2) was measured. Arteriovenous oxygen content difference (AVDO_2) and oxygen extraction fraction (OEF) were calculated and compared simultaneously. The patients were grouped according to the critical value of SjvO_2 (70%), AVDO_2 (4 ml/dl) and OEF (25%). And the prognosis was compared between the two groups.Results SjvO_2 of severe group was significantly higher than non-severe group ( P0.01), while OEF was lower than non-severe group ( P0.01). The unfavourable prognosis incidence of SjvO_2≥70% group was higher than SjvO_270% group ( P0.01), and the unfavourable prognosis incidence of OEF≤25% group was higher than OEF25% group ( P0.01). There was no remarkable difference of prognosis incidence between AVDO_2≤4 ml/dl group and AVDO_24 ml/dl group ( P0.05).Conclusion SjvO_2 and OEF may objectively reflect brain oxygen metabolism and cerebral blood flow after acute cerebral infarction. Furthermore, they are valuable indicators for predicting prognosis.