PM.53 CRADLE: Community Blood Pressure Monitoring in Rural Africa: Detection of underLying Pre-Eclampsia

Introduction In developing countries pre-eclampsia is under-detected partly due to inadequate training in accurate blood pressure (BP) measurements and insufficient equipment. CRADLE is an international study to evaluate whether the introduction of novel, low-cost, automated BP devices into rural clinics in Tanzania, Zimbabwe and Zambia increases referrals for suspected pre-eclampsia to a central referral hospital. This will be reflected in an increased mean BP in pregnant women presenting centrally. Methods Prospective longitudinal pre- and post-intervention study. BP measurements were taken from consecutive women ≥20 weeks gestation who accessed care at a referral site (N = 694). Intervention: 20 BP devices were distributed to 20 rural antenatal clinics in each country. Post-intervention data was collected the following year (N = 547). Results After adjustment for confounders, there was a significant increase in our primary outcome, post-intervention mean diastolic BP, for all women, implying an increased proportion of referred hypertensive women (2.39 mmHg, p Conclusion Equipping low-skilled community health providers with a novel BP device is feasible and widely accepted, and increased community referrals for suspected pre-eclampsia. A cluster RCT to evaluate the effect of these monitors equipped with traffic light early warning systems, on maternal and fetal outcomes is planned.