Second primary lung cancers developed following different system tumors

Aims and background: This study aimed to investigate clinical characteristics and prognosis of secondarily developed lung tumors in the cases having different system malignancy and to evaluate the relationship with the primary tumor. Methods: Thirty patients diagnosed as second primary lung cancer those admitted to have been included in the study. Results: The patients were grouped; synchronous group (n:7, 16.7%) and metachronous group (n:2, 83.3%). The age of primary malignancy and second primary lung malignancy was median 59.5 (range, 38-82 years), and 63 years (range, 39-83 years) respectively. The rate of quitting smoking among all patients before the diagnosis of lung cancer was 50%, current smoker rate was 30%. Second cancer was detected in 50% of the patients within the first 2.5 years. The most frequent primary localization was larynx (40%). Majority of patients received surgical treatment for primary localized carcinoma, while for secondarily developed carcinoma, the most frequent treatment choice was chemotherapy and/or best supportive care. There was no statistical relationship between the response to treatment of first cancer and the duration of cancer developed secondarily (p=0.36). The overall survival of groups was found 24 months (95% confidence interval: 18.30 months) and 12 months (95% confidence interval: 10-14 months) respectively for synchronous and metachronous groups. Conclusions: Close follow-up on pulmonary system especially within the first 2.5 years after primary disease and encouragement on quitting smoking is important.