Association study of the Ubiquilin gene with Alzheimer's disease

Abstract Recently, the ubiquilin 1 gene has been proposed as a major candidate gene for AD. Here, we have investigated the potential impact of the UBQ-8i polymorphism (rs12344615) within this gene on the risk of developing AD. No association of this polymorphism with the disease was observed in a large French case–control population. Furthermore, no relationship between this polymorphism and Aβ load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected.