Impact of a protein and energy dense nutritional supplement containing eicosapentaenoic acid on weight-losing patients with head and neck cancer

8112 Background: Patients with squamous cell cancer of the head and neck (HNSCCa) often lose weight. Under-nutrition is associated with increased postoperative complications and mortality (Nozoe, 2002). A protein and energy dense nutritional supplement (SUP) containing the omega-3 fatty acid eicosapentaenoic acid (EPA) can increase weight and lean body mass (LBM), and improve physical activity and quality of life in pancreatic cancer patients (Fearon et al, 2003; Moses et al, 2004). The purpose of this study was to determine the impact of pre- and peri-operative use of the SUP on weight-losing HNSCCa patients. Methods: Preoperatively, HNSCCa patients with at least 5% premorbid weight loss anticipating surgical resection with curative intent (+/- chemoradiation) were offered 2 cans of SUP (300 kcal, 16g protein, 1g EPA/can) daily beginning at least 2 weeks before surgery. Weight was measured at baseline, hospital admission, and discharge. LBM was measured using bioelectrical impedance at baseline and at ho...