Cerebrospinal fluid immunoglobulins are increased in neonates exposed to Zika virus during foetal life: Cerebrospinal fluid immunoglobulins and Zika virus.

ASTRACT Objective To compare immunoglobulin levels in cerebrospinal fluid (CSF) of neonates exposed to Zika virus (ZIKV) during foetal life (cases) with levels in CSF of control neonates. Methods We identified 16 neonates who underwent lumbar puncture (LP), during the ZIKV epidemic (December/2015 to March/2016) whose mothers reported ZIKV clinical symptoms during gestation (cases). Congenital microcephaly was defined as head circumference ≤31.9 cm (boys) and ≤31.5 cm (girls) for term neonates, or ≤2 standard deviations below the mean for premature ( Results 13 controls were included. IgM, IgA, IgG, IgK, and IgL were significantly higher among cases (p Conclusion Neonates exposed to ZIKV infection during gestation present with elevated distinct immunoglobulins in CSF, both in cases that developed microcephaly and in cases that did not.