P-02THE ETHANOL INDUCED-TLR4/NLRP3 INFLAMMATORY RESPONSE IN MICROGLIAL CELLS CAUSES BLOOD BRAIN BARRIER DYSFUNCTIONS

We have previously reported that ethanol, by activating the innate immune receptors TLR4, triggers signalling inflammatory response, causing gliosis, neuroinflammation and brain damage. Ethanol can also activate other immune receptors, as NOD-like-receptors (NLRs), in particular the NLRP3-inflammasome in astroglial cells, stimulating the caspase-1 activation that allows …