Lymphatic PD-L1 expression restricts tumor-specific CD8+ T cell responses

INTRODUCTION ABSTRACT INTRODUCTION MATERIAL AND METHODS RESULTS DISCUSSION AUTHOR CONTRIBUTIONS COMPETING INTERESTS REFERENCES Lymphatic vessels play an essential role in the generation of adaptive immune responses, providing a transport route for antigen and antigen-presenting cells (APCs) from peripheral tissues to secondary lymphoid organs such as lymph nodes (LNs), and for freshly primed lymphocytes from the LNs to the central circulation. Likewise, within the LNs, lymphatic sinuses orchestrate the lymph flow, antigen entry into the parenchyma, and immune cell migration. Lymphatic endothelial cells (LECs) that line all lymphatic vessels and sinuses have recently emerged as direct, antigen-dependent and independent regulators of adaptive immunity, in particular of dendr ...