Abstract 5297: Chromosomal instability as a prognostic marker in cervical cancer

Previous studies have demonstrated that chromosomal instability (CIN) is a consistent feature of the majority of solid tumors. In this current study, we sought to examine the published CIN70 gene signature in a cohort of cervical cancer patients treated at the Princess Margaret (PM) Cancer Centre (n = 79) and an independent cohort of The Cancer Genome Atlas (TCGA) cervical cancer patients (n = 130). Patients with a high CIN70 score had a higher number of copy number alterations (Spearman9s correlation coefficient (r) = 0.28, p Citation Format: Christine How, Jeff Bruce, Jonathan So, Melania Pintilie, Benjamin Haibe-Kains, Angela Hui, Blaise Clarke, David Hedley, Richard Hill, Michael Milosevic, Anthony Fyles, Kenneth W. Yip, Fei-Fei Liu. Chromosomal instability as a prognostic marker in cervical cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5297. doi:10.1158/1538-7445.AM2015-5297