Cow Brain Consumption Causes Hypercholesterolemia: An in Vivo Study

Background: Organ meats are rich in cholesterol and saturated fats. The experiment was conducted to investigate the effects of cow brain consumption on blood cholesterol level and possible histomorphological changes of liver, heart and kidney in Swiss albino mice.Methods: Total twenty (20) Swiss albino mice (aged 3 weeks; average weight 20-25gm) were taken and randomly divided into group A and group B. Each group consisted of ten (10) mice. The group A was fed with normal mice pellet and water. On the other hand, cow brain (2gm/kg body weight orally once daily for 28 days) was supplied to group B. After the experimental tenure, the mice of both groups were sacrificed ethically and the samples (Blood, liver, heart and kidney) were collected for investigation.Result: Total cholesterol (TC), triglyceride level (TG) and low density lipoprotein level (LDL) significantly (**p<0.01) increased as well as high density lipoprotein level (HDL) significantly (**p<0.01) decreased in group B. In the gross observation, pale with hemorrhagic liver, fat accumulation at the base of the heart and peri renal fat deposition were found in group B of mice. Congestion and dilation in both central and portal vein, marked lymphocytic infiltration and fatty infiltration in liver, wide separation of cardiac muscle fiber in ventricular myocardium, glomerular and tubular fatty infiltration of kidney were also found in histomorphological study. Therefore, the present findings presage that cow brain consumption might have baleful effects on health.