Effect of ulinastatin in heavy heart failure patients with coronary heart disease

Objective To investigate the therapeutic effect of ulinastatin in treatment for heavy heart failure patients with coronary heart disease (CHD).Methods Eighty-two patients with heavy heart failure (NYHA ratings Ⅲ ～ Ⅳ class) and CHD were randomly divided into two groups,all patients used diuretic,angiotensin converting enzyme,etc.And test group was given intravenous drip with ulinastatin for 7 days.The CRP,NT-proBNP and the left ventricular ejection fraction (EF) changes were observed.Results After treatment,CRP and NT-proBNP could be reduced,the clinical heart function of the patients in the two groups was improved; the left ventricular EF of patients in the test group was higher than that in the control group.Conclusion Conventional treatment plus ulinastatin could significantly improve the immune condition and reduce the inflammatory reaction in CHF patients. Key words: Ulinastatin;  Coronary heart disease (CHD);  Chronic heart failure (CHF);  pro-BNP;  CRP