Sympathetic Overactivity Contributes to the Pathogenesis of Non-alcoholic Fatty Liver Disease During Diet-induced Obesity

Non-alcoholic fatty liver disease (NAFLD) is associated with the development of obesity and is a significant contributor to chronic liver, metabolic, and cardiovascular diseases. We have recently shown that hepatic sympathetic nerve activity is significantly elevated in mice fed a high fat diet (HFD; 33±2 vs. 63±5 spikes/s, normal chow vs. HFD; p 0.05) or visceral adipose tissue mass in normal chow or HFD fed animals. However, HFD resulted...