The mechanisms of the realization of the effect of glucocorticoids in aging

: The interaction of glycocorticoids with serum transport proteins, plasma membranes and rat liver cytoplasmic receptors progressively declines during ontogenesis, reaching its minimum at 24 months of age. Glycocorticoid receptor complexes (GRCs) binding to the rat liver nuclei and their residual fractions as well as the glycocorticoid-induced initiation of RNA-synthesis also decrease with age. The GRCs are shown to be capable of association with nuclear envelope, nuclear matrix and RNA-containing nuclear fraction isolated from the rat liver. The intracellular glycocorticoid receptor recycling requires fresh synthesis of the RNA and protein.