substance Pによる血管透過性亢進のneutral endopeptidaseによる調節

To determine whether neutral endopeptidase (NEP) modulates substance P-induced increase in vascular permeability, we examined the effects of an NEP inhibitor and of other protease inhibitors on plasma extravasation induced by intradermal injection of substance P in guinea pig skin. The substance P-induced plasma extravasation was increased by an NEP inhibitor phosphoramidon. Other protease inhibitors, however, did not affect the response. SP1-9, the primary degrading product of substance P by NEP, did not induce any significant plasma extravasation.The results suggested that NEP modulates substance P-induced increase in vascular permeability in the skin.