Abordaje Integral Para la Caracterización in Vitro de la Dinámica Endotelial

Cardiovascular diseases constitute one of the major reasons of death with high prevalence in the western industrialized societies. Endothelial dysfunction plays a fundamental role in physiopathological mechanisms and it is considered a syndrome with systemic manifestations associated with cardiovascular significant morbidity and mortality. The concept of endothelial dysfunction might spread up to the vessels that irrigate the vascular wall and even more, the bony marrow and the progenitor cells of endothelium. The aim of this project is the implementation of an integral system for real-time processing of pressure, flow, vascular dimension, field of velocity profile and wall shear stress simultaneously (using Doppler velocimetry, computational fluid dynamics, piezoelectric and strain gauge sensors), in order to assess endothelial function. This system will constitute the gold standard of an immediate miniaturization (using bioMems), for evaluating the endothelium capability, in accordance to the development of implantable sensors with capacity of acquisition of additional magnitudes of the whole system, as temperatures, PH and Nitric Oxide.