Risk Factors Related with Recurrence of Uterine Myoma after Myomectomy

Objective:To investigate the risk factors related with recurrence of uterine myomas after myomectomy.Methods:We prospectively analyzed 251 cases of uterine myoma from May.2000 to Jau.2005 and followed up regularly after operation.Results:17 patients of total 251 cases(6.77%,17/251) were lost during follow-up.The data showed 54 cases recurred(23.1%,54/234),44 cases(24.2%,44/182) in Laproscopic myomectomy(LM) group and 10 cases(19.2%,10/52) in Abdominal myomectomy(AM) group,no significant difference between them.Single factor analysis showed the factors related to recurrence were volume of uterine,location,size and number of myomas.Cox regression analysis suggested that the predictive factors for myoma relapse are diameter of myomas ≥10 cm(P=0.004,RR=2.504,95%CI 1.626,6.896),multiple myomas(P=0.001,RR=3.349,95%CI 1.626,6.896),and intramural myomas(P=0.021,RR=2.103,95%CI 1.114,3.639).3 recurred patients underwent second-operation(5.6%,3/54,2 total hysterectomy and 1 myomectomy).Conclusions:Recurrence rate of myomas between LM and AM is not significant.The predict factors are size and number of myomas.Patients with multiple or larger myomas(diameter≥10 cm) prone to recur.