Distinct and separable activities of the endocytic clathrin coat components Fcho1/2 and AP-2 in developmental patterning

Clathrin-mediated endocytosis requires the coordinated spatial and temporal recruitment of adaptor, sorting and cargo proteins. Traub and colleagues investigate this process during zebrafish development and report that the AP-2 adaptor protein complex has a key, early role in clathrin-coated bud formation. Fcho1/2, though necessary for proper development, seems to act downstream of AP-2.