A Facile 1,3-Dipolar Cycloaddition of Azomethine Ylides to 2-Arylidene-1,3-indanediones: Synthesis of Dispiro-Oxindolylpyrrolothiazoles and Their Antimycobacterial Evaluation.

Shanmugavel Uma Maheswari,Kamaraj Balamurugan,Subbu Perumal,Perumal Yogeeswari,Dharmarajan Sriram

A Facile 1,3-Dipolar Cycloaddition of Azomethine Ylides to 2-Arylidene-1,3-indanediones: Synthesis of Dispiro-Oxindolylpyrrolothiazoles and Their Antimycobacterial Evaluation.

2011

Shanmugavel Uma Maheswari
Kamaraj Balamurugan
Subbu Perumal
Perumal Yogeeswari
Dharmarajan Sriram

Compound (IVg) exhibits the highest in vitro activity against Mycobacterium tuberculosis H37Rv (MTB) and is about 3.4 times more active than ciprofloxacin and 5.4 times more potent than ethambutol.

Keywords:

Combinatorial chemistry
Antimycobacterial
Mycobacterium tuberculosis H37Rv
Organic chemistry
1,3-Dipolar cycloaddition
Ethambutol
Chemistry

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