Comparison of Pharmacokinetic and Cell Binding Properties of Turkey Cu-Sod and E. Coli Mn-Sod

The pharmacokinetics in rats and cell fixation properties of coli Mn-SOD are compared with those of Cu-SODs extracted from turkey blood. Despite similarities in molecular weight and pi the different enzymes show different characteristics. The results are discussed with respect to the mechanism of antiinflammatory activity of superoxide dismutase.