N-acyl-3-hydroxy-β-lactams as key intermediates for taxotere and its analogs

Abstract (3 R ,4 S )-3-(protected hydroxy)-4-substituted β-lactams bearing N -alkoxycarbonyl, N -arloxycarbonyl, and N -carbamoyl groups are found to be useful for the synthesis of taxotere and its analogs through coupling with baccatin III.