AB0686 Association between the immunological profile of the patients with primary sjÖgren syndrome and occurrence of the extraglandular manifestations

Background Primary Sjogren’s syndrome (pSS) is a chronic inflammatory disease characterized by lymphocytes and plazmocytes infiltration of exocrine glands. Typical clinical manifestations of pSS are symptoms of dry mouth and dry eyes, but other organs can be also involved (extraglandular manifestations). Immunological profile of patients with pSS is very heterogeneous. Objectives The aim of our study was to assess the association between the immunological profile of patients with primary Sjogren Syndrome and the occurrence of extraglandular manifestations at the time of diagnosis setting. Methods The studied group comprised of 58 patients (pts) (1 male and 57 female) aged 48±14.8 years with the diagnosis of pSS according to 2002 year classification criteria. The patients were divided into two groups with or without extraglandular manifestations of pSS, respectively: group I - 40 patients (mean age 47 years), and group II -18 patients (mean age 49). The presence of anti-nuclear antibodies (ANA), anti-Sjogren’s syndrome A antibodies (SSA), anti-Sjogren’s syndrome B antibodies (SSB), anti-cyclic citrullinated peptide (aCCP), α-fodrin IgG and IgA, anti-cardiolipin (aCl) IgM, IgG, anti-β2-glycoprotein I IgG and IgM, lupus anticoagulant (LAC) and rheumatoid factors IgM (RF IgM) was determined in sera of the pts. Results In the group I the following extraglandular manifestations were revealed - oligoarthritis in 31 pts (53%); Raynaud phenomenon in 16 pts (28%); leucocytoclastic vasculitis in 12 pts (21%); nervous system involvement in 8 pts (14%); interstitial lung disease in 3 pts (5%); pericarditis in 2 (3%).The following organ non-specific autoantibodies were detected: ANA (83% of pts); anti-SSA (70% of pts); anti-SSB (37% of pts); aCCP (22% of pts); anti α-fodrin IgG (33% of pts) and IgA (25% of pts); aCl IgM (22% of pts); aCl IgG (9% of pts); anti-β2-glycoprotein I IgG (3% of pts) and IgM (5% of pts); LAC (7% of pts) and RF IgM (88% of pts). Statistically significant correlations between the immunological profile of the patients with primary Sjogren Syndrome and occurrence of the extraglandular manifestations were not established. Conclusions The extraglandular manifestations are present in 70% of primary Sjogren Syndrome patients, the most common manifestations are: oligoarthritis; Raynaud phenomenon and leucocytoclastic vasculitis. ANA, RF IgM, anti-SSA antibodies are the most commonly detected autoantibodies.There are no differences in immunological profile between primary Sjogren Syndrome patients with or without extraglandular manifestations Disclosure of Interest None Declared