Catenin Family Genes Are Not Commonly Mutated in Hereditary Diffuse Gastric Cancer

Background: Approximately one third of the hereditary diffuse gastric cancer (HDGC) families carry germline mutations in the E-cadherin gene ( CDH1 ). Risk prediction in members of families with this rare but deadly cancer could be improved by the identification of additional HDGC genes in non- CDH1 families. Methods: Affected individuals from 22 CDH1 mutation-negative families were screened for germline mutations in four catenin genes: CTNNA1 , CTNNB1 , JUP , and CTNND1 . Catenins interact closely with E-cadherin molecules in cells, and are therefore logical candidate genes for mutation screening in HDGC families. Results: No nonsynonymous variants were seen in CTNNA1 , CTNNB1 , or CTNND1; only JUP contained nonsynonymous variants, of which only two rare variants were predicted to be deleterious. Conclusion: Catenin genes are not commonly mutated in non- CDH1 HDGC families. Impact: Germline mutations in CTNNA1 , CTNNB1 , JUP , or CTNND1 are unlikely to play a major role in HDGC. Cancer Epidemiol Biomarkers Prev; 21(12); 2272–4. ©2012 AACR .