The course of asthma: a population-based 10-year study examining asthma remission in children diagnosed with asthma in preschool.

BACKGROUND The natural course of asthma may differ depending on the age of onset. OBJECTIVE To investigate predictors of asthma remission with a focus on age of asthma onset. METHODS The study was a retrospective birth cohort of children with asthma in Saskatchewan, Canada. Using the Saskatchewan Ministry of Health databases, we identified children with a diagnosis of asthma in the first 6 years of life and who had at least 10 years of follow-up after diagnosis (n=22,563). Of these, we included 6,393 children either with persistent asthma [≥ 1 physician visit or hospitalization for asthma (PVHA) during each year of follow-up] and those who had remission (had PVHA in the first year after diagnosis but at some point during the follow-up no longer received PVHA until end of the study). We used survival analysis to examine associations between remission and age of asthma onset. RESULTS Of the study participants, 87.2% had early-onset (≤ 3 years) and 12.8% had late-onset (4-6 years) asthma. Over the 10-years of follow-up, rate of asthma remission was 37 per 100 person-years. Early-onset asthma (HR = 1.10, 95%CI: 1.01-1.20), being female (HR = 1.12, 95%CI: 1.07-1.18), living in a rural (HR = 1.20, 95%CI: 1.14-1.27) and medium urban (HR = 1.16, 95%CI: 1.08-1.26) location were positively associated with remission while history of atopy decreased likelihood of remission (HR = 0.73, 95%CI: 0.54-0.97). CONCLUSION Most children with asthma experienced remission, especially those with onset of symptoms within the first 3 years of life. This article is protected by copyright. All rights reserved.