Lentiviral Vectors in Immunotherapy

Genetic immunotherapy can be defined as a therapeutic approach in which therapeutic genes are introduced into defined target cell types to modulate immune responses. A major challenge for this therapeutic strategy is the delivery of these genes into target cells in an efficient, stable manner. Possibly one of the best systems to achieve this is the use of lentivi‐ ral vectors (lentivectors) as gene carriers, as they are capable of transducing both dividing and resting cells [1].