Tec family tyrosine kinase inhibitors and pharmaceutical compositions containing these compounds thiazolyl

Field of the Invention The present invention relates to compounds of formula (I) wherein the major meanings of the substituents are: Q 1 is thiazolyl; Q2 is aryl or heteroaryl, optionally independently substituted with one or more R1a; Z is (1) oxygen, (2) sulfur, (3) -NR4, (4) -CR4R5-, (5) -CR4R5-O-CR4aR5a, (6) - CR4R5-NR4b-CR4aR5a, (7) -CR4R5-S-CR4aR5a, (8) -CR4R5-O-, (9) O-CR4R5, (10) - CR4R5-NR4b, (11) NR4b-CR4R5-, (12) -CR4R5-S, (13) S-CR4R5-, (14) S (O) q- wherein q is 1 or 2, (15) -CR 4 R 5 -S (O) q -, or (16) S (O) q-CR 4 R 5; R1 and R1a are independently (1) hydrogen or R6, (2) hydroxy or -OR6, (3) thiol, or -SR6, (4) -C (O) qH, - C (O) q R 6 or -OC (O) q R 6, (5) -SO 3 H or -C (O) q R 6, (6) halogen, (7) cyano, (8) nitro, (9) -Z 4 -NR7R8-, (10) -Z4-N (R9) -Z5-NR10r11-, general group, (11) -Z4-N (R12) -Z5-R6-, or (12) -P ( O) (OR6) 2; R2 and R3 are each independently hydrogen, -Z4-R6a or -Z4-NR7aR8a - and their pharmaceutically acceptable salts, for use in the manufacture of a medicament for the treatment of disorders associated with the tyrosynthase tec family, such as cancer, immunological disorders, and allergic diseases, and the invention. pharmaceutical compositions containing the compounds. HE