Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population.

Context: Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to the well-described FTO and MC4R genetic variants. Objective: This study aimed to examine 13 previously reported obesity and/or BMI-associated loci for associations with obesity in Chinese. Design and Study Participants: This was a cross-sectional case-control study in 470 obese cases (BMI ≥27.5 kg/m2) and 700 normal-weight controls (18.5 ≤ BMI ≤ 23.0 kg/m2). Results: A significant association with obesity could be replicated (one tailed P < 0.05) in seven of the 13 single-nucleotide polymorphisms (SNPs) in the case-control study. These included GNPDA2 rs10938397 (P = 7.3 × 10−4); FTO rs8050136 (P = 8 × 10−4); MC4R rs17782313 (P = 1.2 × 10−3); KCTD15 rs29941 (P = 8 × 10−3); SFRS10-ETV5-DGKG rs7647305 (P = 0.023); SEC16B-RASAL2 rs10913469 (P = 0.041); and NEGR1 rs3101336 (P = 0.046). Combined genetic risk scores were calculated, and we observed ORs ra...