Pediatric patients report lower Health-Related Quality of Life in daily clinical practice compared to new normative PedsQLTM data.

AIM To compare Health-Related Quality of Life (HRQOL) of pediatric patients with newly collected HRQOL data of the general Dutch population, explore responses to individual items and investigate variables associated with HRQOL. METHODS Children (8-12y) and adolescents (13-17y) from the general population (N=966) and from a pediatric population (N=1209), completed the Pediatric Quality of Life Inventory (PedsQLTM ) online via the KLIK Patient Reported Outcome Measures portal. PedsQLTM scale scores were compared between groups with independent t-tests, by age-group and gender. Responses to PedsQLTM items were explored using descriptive analyses. Linear regression analyses were performed to determine which variables were associated with HRQOL. RESULTS Pediatric patients reported worse HRQOL than the general population on all PedsQLTM scales (p≤.001, d=0.20-1.03), except social functioning, and a high proportion reported problems on PedsQLTM items, e.g., 'I have trouble sleeping'. Younger age, female gender and school absence were negatively associated with HRQOL (β=-0.37-0.10, p≤.008). CONCLUSION Pediatric patients reported lower HRQOL than the general population, and school absence, female gender and younger age was associated with lower HRQOL. The results underline the importance to structurally monitor pediatric patients' HRQOL in clinical practice to detect problems and offer the right help on time.