ОЦЕНКА ЦЕРЕБРОПРОТЕКТОРНОЙ АКТИВНОСТИ КОМБИНАЦИЙ НООТРОПОВ С МЕЛАКСЕНОМ ПОСРЕДСТВОМ МОРФОЛОГИЧЕСКОГО АНАЛИЗА НА МОДЕЛИ ИШЕМИИ ГОЛОВНОГО МОЗГА У КРЫС

The cerebroprotective activity of nootropics in combination with melaxen (melatonin containing drug) was investigated by a comprehensive morphological analysis using an experimental model of acute cerebral ischemia in rats. According to the obtained data, a preventive use of vinpocetine in combination with melaxen signifi cantly reduces the degree of lethality among experimental animals and the severity of ischemic brain damage. A suggestion is made about the potential feasibility of melatonin-containing drugs for increasing the effi cacy of neuroprotection in cerebral ischemia.