THE RELATION BETWEEN HAEMOGLOBIN LEVEL AND PLASMA PROTEINS ON INDUCTION DOSE OF THIOPENTONE AND PROPOFOL

Objectives To study the relation between haemoglobin level and plasma proteins on induction dose of thiopentone and propofol so as to decide the difference in doses in anaemic and malnourished indivisuals. Methodology A randomized, prospective study was carried out to find the effect of haemoglobin level and serum proteins on induction dose of Thiopentone and Propofol. In this study, 100 patients (ASA I-II) of either sex between 12-70 years of age, undergoing elective surgical procedure were randomly divided into two groups (A & B) of 50 each. Group A received thiopentone and group B received propofol as induction agents. They were further divided into 3 groups (1,2 and 3) -1 was control group, 2 was low haemoglobin group (<12 gm%) and 3 was low serum protein group (<6mg%). Results Requirement of thiopentone was significantly decreased in low haemoglobin group (23.74%) and low protein group (13.03%) (p<0.05) as compared to control group. Similarly, requirement of propofol was also significantly decreased in low haemoglobin (30.84%) and low protein group (26.15%) (p<0.05) as compared to control group. Conclusion It was concluded that the dose of induction should be reduced in anaemic and malnourished patients and the dose should be titrated according to clinical effects along with mg/kg dose basis