Discovery of potent and selective DP1 receptor antagonists in the azaindole series

Yves Leblanc,Patrick Roy,Claude Dufresne,Nicolas Lachance,Zhaoyin Wang,Gary O’Neill,Gillian Greig,Danielle Denis,Marie-Claude Mathieu,Deborah Slipetz,Nicole Sawyer,Nancy N. Tsou

Discovery of potent and selective DP1 receptor antagonists in the azaindole series

2009

Yves Leblanc
Patrick Roy
Claude Dufresne
Nicolas Lachance
Zhaoyin Wang
Gary O’Neill
Gillian Greig
Danielle Denis
Marie-Claude Mathieu
Deborah Slipetz
Nicole Sawyer
Nancy N. Tsou

Azaindole based structures were evaluated as DP1 receptor antagonists. This work has lead to the discovery of potent, selective and distinct DP1 receptor antagonists.

Keywords:

Chemical synthesis
Organic chemistry
Carboxylic acid
In vivo
Pharmacokinetics
Biochemistry
Receptor
Chemistry
dp1 receptor
Structure–activity relationship
Stereochemistry
benzene derivatives
Antagonist

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