Patient-reported symptoms and Canadian Health Utility scores in esophageal cancer patients.

6607 Background: Health utility scores (HUS) are an increasingly important tool to help determine the cost-effectiveness of therapies worldwide. The EQ-5D-3L is a validated tool for deriving HUS, with reference data in numerous populations, but there is limited information on the role that individual symptom complexes (SC) play in determining HUS in Esophageal cancer (EC) patients. Methods: A cross-sectional survey of EC patients at Princess Margaret Cancer Centre (2012-2014) assessed EQ-5D-3L and FACT-E. EQ-5D scores were converted to HUS using Canadian references. SC were developed: domains from FACT-E were identified and grouped to represent symptoms such as pain, dysphagia, fatigue, dyspnea, nausea and loss of appetite. Multivariable regression analysis was performed to assess associations between SC and HUS, adjusting for age, sex, and stage of disease. Results: Of 197 patients, median age was 67 (range 32-93) years, 76% were male, with stage I/II-IVA/IVB (6%/66%/28%) disease. Mean (SE) HUS were 0.90...