[Study on the association between gene polymorphism of ENPP1 and left ventricular hypertrophy: a Guangzhou Biobank Cohort Study-CVD].

：Objective To examine theassociation between genetic polymorphism of rs1409181 in ectonucleotidepyrophosphatase/phosphodiesterase 1 (ENPP1) and left ventricular hypertrophy (LVH) amongolder Chinese in Guangzhou. Methods 390 subjects aged ≥50 years were randomly selected from the Guangzhou BiobankCohort Study-CVD. Information on personal history, blood pressure, fasting plasma glucoseand lipids were collected. Color Doppler ultrasound was used to measure the indicators ofLVH, including left ventricular internal diastolic diameter (LVIDD) , thickness of theinterventricular septum diastolic wall (IVSD) and the posterior wall diastolic diameter(LVPWD). LVIDD was calculated using Devereux ventricular mass (LVM)equation while the Leftventricular mass index (LVMI) equation was used to estimate LVH. The genotype of rs1409181was determined by Taqman SNP genotyping kits using the ABI 7900HT real time PCR system.Results In the GG, CG and CC genotype groups, the proportions of LVH were 21.5%, 28.2% and37.5% respectively. Compared with GG, the adjusted odds ratios (95% confidence interval)for the LVH were 1.39(0.78-2.50) and 2.36(1.21-4.60) for CG genotype and CC genotype ofENPP1 respectively (P for trend=0.01). Conclusion Polymorphism of ENPP1 gene rs1409181 wasassociated with LVH in the older Chinese people in Guangzhou. Key words: Left ventricular hypertrophy; Ectonucleotidepyrophosphatase/phosphodiesterasel; Polymorphism