THE DEVELOPMENT OF THE COMBINED MEDICINAL HERBAL REMEDIES FOR STOMATOLOGICAL AND OTORHINOLARYNGOLOGICAL PRACTICE

Aim - to develop a series of combined medicinal herbal remedies «Dentos» for dental and otorhinolaryngological practice, in which complex effect on different elements of the infectious inflammatory process is achieved by the combination of several groups of biologically active compounds. Materials and methods. Basic phytocomposition is a medicinal preparation "Dentos", which is composite alcohol-water extract on 70% ethanol from the five types of medicinal plant raw materials: the leaves of Eucalyptus viminalis, the herb of Echinacea purpurea, the flowers of Calendula officinalis, the bark of Quercus robur and the oil of Caryophyllus aromaticus. Dosage forms based on it are the following: dental gel, medicinal lozenges, therapeutic and prophylactic toothpaste. The experimental research involved the methods of marketing analysis, various technological methods (extraction methods of developing medicinal preparations and instrumental definition of technological parameters), and modern methods of pharmaceutical analysis: chromatographic methods (TLC), UV-spectroscopy, HPLC, chemical methods (qualitative test-tube reaction). Results. The blend composition of the developed medicinal preparations was proposed (dental gel, medicinal lozenges, therapeutic and prophylactic toothpaste), the technology of their production was elaborated, the quality parameters were studied and the approaches to standardization of remedies were substantiated.