Quantitative evaluation on hypervascular liver metastasis and hepatocellular carcinoma in contrast enhanced ultrasound

Objective To investigate the value of quantitative evaluation on hypervascular liver metastasis and hepatocellular carcinoma(HCC) in CEUS.Methods Twenty-five patients with hypervascular liver metastasis and 82 patients with HCC confirmed pathologically underwent CEUS,and the tumors were quantitatively evaluated and statistical analyzed.Results The washout time(WT) and enhancement duration time(EDT) of liver metastasis was(26.59±9.34)s and(10.60±3.58)s,respectively,while of HCC was(61.99±50.97)s and(46.42±50.45)s,respectively(t=3.93,-3.54,P0.01).Using WT and EDT at the standard cut-off value of 28.5 s and 15.5 s had the maximum Youden index,and resulted in the sensitivity of 87.36% and 85.37%,while the specificity of 75.01% and 92.03%,respectively.There was no significant statistical difference in arrival time and time to peak between hypervascular liver metastasis and HCC.Conclusion According to quantitative analysis parameters EDT and WT,hypervascular liver metastasis and hepatocellular carcinoma can be differentiated conveniently and noninvasively with CEUS.