Automatic mandible segmentation from CT image using 3D fully convolutional neural network based on DenseASPP and attention gates.

In cranio-maxillofacial surgery, it is of great clinical significance to segment mandible accurately and automatically from CT images. However, the connected region and blurred boundary in teeth and condyles make the process challenging. At present, the mandible is commonly segmented by experienced doctors using manually or semi-automatic methods, which is time-consuming and has poor segmentation consistency. In addition, existing automatic segmentation methods still have problems such as region misjudgment, low accuracy, and time-consuming. For these issues, an automatic mandibular segmentation method using 3d fully convolutional neural network based on densely connected atrous spatial pyramid pooling (DenseASPP) and attention gates (AG) was proposed in this paper. Firstly, the DenseASPP module was added to the network for extracting dense features at multiple scales. Thereafter, the AG module was applied in each skip connection to diminish irrelevant background information and make the network focus on segmentation regions. Finally, a loss function combining dice coefficient and focal loss was used to solve the imbalance among sample categories. Test results showed that the proposed network obtained a relatively good segmentation result, with a Dice score of 97.588 ± 0.425%, Intersection over Union of 95.293 ± 0.812%, sensitivity of 96.252 ± 1.106%, average surface distance of 0.065 ± 0.020 mm and 95% Hausdorff distance of 0.491 ± 0.021 mm in segmentation accuracy. The comparison with other segmentation networks showed that our network not only had a relatively high segmentation accuracy but also effectively reduced the network's misjudgment. Meantime, the surface distance error also showed that our segmentation results were relatively close to the ground truth. The proposed network has better segmentation performance and realizes accurate and automatic segmentation of the mandible. Furthermore, its segmentation time is 50.43 s for one CT scan, which greatly improves the doctor's work efficiency. It will have practical significance in cranio-maxillofacial surgery in the future.