Rate and extent of mitragynine and 7‐hydroxymitragynine blood–brain barrier transport and their intra‐brain distribution: the missing link in pharmacodynamic studies

Siti R. Yusof,Mahathir Mohd Uzid,Eng‐Huat Teh,Nur Aziah Hanapi,Mazlin Mohideen,Ahmad Saifuddin Mohamad Arshad,Mohd Nizam Mordi,Irena Loryan,Margareta Hammarlund-Udenaes

Rate and extent of mitragynine and 7‐hydroxymitragynine blood–brain barrier transport and their intra‐brain distribution: the missing link in pharmacodynamic studies

2018

Siti R. Yusof
Mahathir Mohd Uzid
Eng‐Huat Teh
Nur Aziah Hanapi
Mazlin Mohideen
Ahmad Saifuddin Mohamad Arshad
Mohd Nizam Mordi
Irena Loryan
Margareta Hammarlund-Udenaes

Mitragyna speciosa is reported to be beneficial for the management of chronic pain and opioid withdrawal in the evolving opioid epidemic. Data on the blood-brain barrier (BBB) transport of mitragyn ...

Keywords:

Anesthesia
Psychology
Mitragynine
Pharmacodynamics
Blood–brain barrier
7-Hydroxymitragynine
Pharmacokinetics
Pharmacology
Efflux
Mitragyna speciosa
Slice preparation
In vivo
Transporter

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