Heteroatom‐Guided, Palladium‐Catalyzed, Site‐Selective C ? H Arylation of 4H‐Chromenes: Diastereoselective Assembly of the Core Structure of Myristinin B through Dual C ? H Functionalization

A highly site-selective, heteroatom-guided, palladium-catalyzed direct arylation of 4H-chromenes is reported. The CH functionalization is driven not only by the substituents and structure of the substrate but also by the coupling partner being used. The diastereoselective assembly of the core structure of Myristinin B has been achieved by using a dual CH functionalization strategy for regioselective direct arylation.