Interaction of the cholinesterases of warm-blooded animals with esters of N-(β-hydroxypropyl)piperidines and the methiodides

The influence of esters of N-(β-hydroxypropyl)pyridines (alkyl radicals from CH3 to C4H9) on the enzymatic activity of acetylcholinesterase (ACE) from human blood erythrocytes and on that of butyrylcholinesterase (BCE) from horse blood serum has been studied. At pH 7.5 and 25°C the majority of the piperidine derivatives inhibit reversibly (by the competitive type of inhibition) both ACE and BCE, their inhibiting properties depending only slightly on the presence of the corresponding alkyl radicals in the acid part of the molecule.